![]() ![]() Over the 9 years of surveillance, the fluconazole resistance rate continued to increase, rising from 5.7 (7/122) to 31.8% (236/741), while that for voriconazole was almost the same, rising from 5.7 (7/122) to 29.1% (216/741), with no significant statistical differences across the geographic regions. In addition, 16.9 (370/2192) and 71.7% (1572/2192) of the isolates were of non-wild-type phenotype to itraconazole and posaconazole, respectively. Overall, 22.2% (823/3702) of the isolates were resistant to fluconazole, with 90.4% (744/823) being cross-resistant to voriconazole. Antifungal susceptibility was determined by Clinical and Laboratory Standards Institute disk diffusion (CHIF-NET10-14, n = 1510) or Sensititre YeastOne (CHIF-NET15-18, n = 2192) methods. Species identification was carried out by mass spectrometry or rDNA sequencing. tropicalis isolates ( n = 3702) were collected from 87 hospitals across China. ![]() tropicalis causing invasive candidiasis in China, from a 9-year surveillance study.įrom August 2009 to July 2018, C. Here we report on the epidemiology and antifungal susceptibility of C. There have been reports of increasing azole resistance in Candida tropicalis, especially in the Asia-Pacific region.
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